ProductHighlights:
TheInfiniumCytoSNP-850Kv1.1BeadChipisthefirstSNP-basedhumanmicroarraytoleveragethelatestinputfromtheinternationalcommunityforcytogenomicsstudies.ThegenelistwasdefinedbasedoncontentfromtheInternationalCollaborationforClinicalGenomics(ICCG)1andtheCancerGenomicsConsortium(CGC)2,providingacomprehensiveviewofcytogenomicactivity.*ThisenhancedSNPcoverageenablescopynumbercallsassmallas10kbinregionsassociatedwithgeneticdisease.
ThoroughCoverageforConstitutionalandCancerApplications
TheInfiniumCytoSNP-850Kv1.1BeadChipprovidescomprehensivecoverageofcytogeneticallyrelevantgenesonaprovenplatform,helpingresearchersfindvaluableinformationthatmaybemissedbyothertechnologies.Itcontainsapproximately850,000empiricallyselectedsinglenucleotidepolymorphisms(SNPs)spanningtheentiregenomewithenrichedcoveragefor3,262genesofknowncytogeneticsrelevanceinbothconstitutionalandcancerapplications.
HighDetectionSensitivityforLow-levelMosaics
AuniqueattributeoftheInfiniumarraytechnologyistheuseoflong50-merprobesthathavehighspecificitytotheSNPtarget.Thisincreasessensitivityforlow-levelmosaics3andoffershighresolutionforcopy-neutrallossofheterozygosity(LOH).Inaddition,eachSNPisrepresentedinatleast15xredundancytoincreasethesignal-to-noiseratioformakingaccuratecopynumbervariation(CNV)andabsenceofheterozygosity(AOH)callsacrossthegenome.Asfewas10consecutiveprobesarenecessarytomakeaccurateCNVcalls,demonstratingthehighperformanceleveloftheInfiniumassay.
Specifications:
| AssayTime | 3days |
| Hands-OnTime | 1hour5min.forautomated8-beadchipworkflow,6hours15min.formanual8-beadchipworkflow |
| InputQuantity | 200ngDNA |
| Method | Genome-WideGenotypingArray,CytogenomicArray |
| Technology | Microarray |
| VariantClass | SingleNucleotidePolymorphisms(SNPs),LossofHeterozygosity(LOH),ChromosomalAbnormalities,CopyNumberVariants(CNVs) |
| SpecializedSampleTypes | FFPE |
| SystemCompatibility | NextSeq550,iScan |
| SpeciesCategory | Human |
| CancerType | Hematological,SolidTumor |
