ProductHighlights:
The12-sampleHumanCytoSNP-12BeadChipisapowerful,whole-genomescanningpaneldesignedforefficient,high-throughputanalysisofgeneticandstructuralvariationsthataremostrelevanttohumandisease.Thisscalable,provensolutionofferssubstantiallybetterresolutiontodetectsmallerregionsthanfluorescenceinsituhybridization(FISH)orcomparativegenomichybridization(CGH).1
- Completepanelofgenome-widetagsinglenucleotidepolymorphisms(SNPs)andMarkerstargetingallregionsofknowncytogeneticimportance,incorporating~300,000“bestofthebest”SNPswiththehighesttaggingpower
- AverageSNPcallratesandreproducibilityof>99.9%,andlownoiseforcopynumbermeasurements
- Detectmanytypesandsizesofstructuralvariationinthehumangenomethataffectphenotypes,includingduplications,deletions,amplifications,copy-neutrallossofheterozygosity(LOH),andmosaicism
- Processupto12samplesinparallel,increasingsamplethroughputanddecreasingexperimentalvariABIlity
- Processsamplesusingthesingle-tube,PCR-freeInfiniumHDAssaythatrequiresonly200ngDNApersample
- ComprehensivedataanalysiswithintuitiveBlueFuseMultiSoftwarestreamlinescopynumberassessmentandresultsreporting
TheHumanCytoSNP-12BeadChipisoptimizedtodetectcytogeneticabnormalitiesmostrelevanttohumandisease.1-2Contentincludes~300,000SNPstargetingregionsshowntobeimportantforcytogeneticanalysis.Theresultisdensecoverageof~250diseaseregions,includingsubtelomericregions,pericentromericregions,andsexchromosomes,commonlyscreenedincytogeneticslabs.SufficientSNPcoverageisprovidedtodeterminedosagesensitivityof>800genes.
Specifications:
| AssayTime | 3days |
| Hands-OnTime | 1hour5min.forautomated8-beadchipworkflow,6hours15min.formanual8-beadchipworkflow |
| InputQuantity | 200ngDNA |
| Method | Genome-WideGenotypingArray,CytogenomicArray |
| Technology | Microarray |
| VariantClass | SingleNucleotidePolymorphisms(SNPs),LossofHeterozygosity(LOH),ChromosomalAbnormalities,CopyNumberVariants(CNVs) |
| SystemCompatibility | NextSeq550,iScan |
| SpeciesCategory | Human |
| CancerType | Hematological,SolidTumor |
